Pharma

     10 Points to be discussed with Business Executive  
                                                                                                                                                
1. Why Epidure Cream must be co-prescribed for every patient of AD? 
In AD, Skin’s Innate Defense System gets compromised — due to Genetic Mutations, Lipid 
Barrier Disruption and Immune System dysfunction with overactivated NF-kappa signaling 
leading to enhanced skin inflammation. In such cases, skin requires more than an emollient in form 
of an Advanced Supportive Care Formulation (Epidure Cream) that restores and repairs this Skin 
Innate Defense System. 
 
2. What is Skin Innate Defense System? 
The skin's innate defense system is a multi-layered, first-line defense against pathogens & allergens 
that involve physical barriers, chemical and antimicrobial substances, and specialized 
immune cells. It works with help of these physical barriers of the epidermis, chemical secretions 
like sebum and sweat, and immune cells like keratinocytes, macrophages, and dendritic cells that 
detect and destroy invaders.  
 
 
3. Why we say, Epidure Cream is an Advanced Supportive Care Formulation for Atopic Dermatitis?  
We say this as it has been designed with a unique combination of ingredients to complement and 
support the ongoing primary treatment of AD already being taken by patient. 
 
4. Which Ingredients make Epidure Cream an Advanced Supportive Care Formulation? 
Epidure Cream has a unique combination of Ingredients like Glycyrrhetinic Acid along with 
Panthenol, Shea Butter, Allantoin etc. that specifically work on restoring Skin’s Innate Defense 
System in case of AD.  
 
 
5. Why we are calling Epidure a Skin’s Innate Defense Restoration Formula?  
Epidure has a unique combination of ingredients that comprehensively work together to restore 
healthy skin barrier, replenishing lipid matrix and preventing TEWL.  
 
 
 
 
 
6. Why have we mentioned Epidure offers Inside Repair for Outside Healing in our VA?  
There are internal factors in AD (NF-kappa & TNF-alpha), that are exacerbating itching and 
inflammation, and increasing barrier damage. Our Epidure Cream works from inside to control 
these and calm Inflammation, neutralizes free radicals, & control overactivated immune response.  
 
 
7. Which Ingredient is responsible for inside repair for outside healing?  
Glycyrrhetinic Acid inhibits NF-κB, COX-2, TNF-α pathways to calm inflammation and overactive 
Th2 response, and gradually breaks itch-scratch cycle. 
 
 
8. Which Ingredient is responsible for restoring lipid matrix and reduce TEWL? 
Panthenol, Shea Butter, Almond & Sunflower Oils restore lipids and reduce TEWL (Trans-Epidermal 
Water loss) 
 
 
9. Which Ingredient is responsible for healing damaged skin and regenerating healthy skin? 
Allantoin promotes healing and regeneration of skin, and supports healthy cell turnover 
 
10.  Which Ingredient is responsible for controlling Oxidative Stress and Cell-Damage? 
 Rice Bran Oil, Vitamin E & C derivatives neutralize free radicals and protect cells